![]() One study differentiated risk by presence or absence of migraine aura, and did find an increased risk in the migraine with aura population.įurther efforts to extract meaningful findings from the collected research were abandoned as analysis uncovered myriad weaknesses in the available data. In the seven studies focused specifically on the effect of interaction between migraine and combined oral contraceptives, no effect was found. No studies reported odds ratios for stroke risk as a function of estrogen dose in women with migraine, largely due to insufficient sample sizes. Of that small pool of available research, the studies were generally small, and confidence intervals were wide. Fifteen were found to meet the set criteria for inclusion in this survey, and six data sets were used to generate odds ratios for ischemic stroke in women who used combined oral contraceptives containing estrogen in any quantity. Using the GRADE and Newcastle Ottawa scales, independent reviewer pairs assessed the quality of each study’s data. They compiled all relevant English-language studies of adults on exposure to combined oral contraceptives, and reported outcomes of ischemic or hemorrhagic stroke. Rebecca Burch combed through medical science databases PubMed, EMBASE and the Cochrane Library from their inception through January 2016. To examine the potential relationship between migraine with aura, combined oral contraceptives, variations in estrogen levels within those contraceptives, and stroke risk, Dr. ![]() A new study published in Headache sought to examine available research data to confirm whether there is in fact a synergism between migraine and combined oral contraceptives related to stroke risk, and to seek a framework to understand how the two factors may interrelate. Thus, women diagnosed with migraine with aura have been urged to avoid combined oral contraceptives in the past out of concern that the two risk factors would compound. The presence of migraine with aura is known to increase the risk of stroke, especially in women, and research has also shown that the use of combined oral contraceptives (commonly known as birth control pills) is linked to a higher risk of stroke as well. Migraine with Aura, Contraceptives and Stroke Risk From the Journal: Risk of stroke associated with use of estrogen containing contraceptives in women with migraine: A systematic review
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